This netcast explores the rapidly changing world of biotech, with a penchant towards getting a better understanding of who we are and where we are going. The living world will soon be a true substrate for engineering. Our world will change, and so will we.
We bring a first hand account from the scientists that are moving us into this new technological era: the era of biotech.
Guest: Dr. Elizabeth Winzeler, Ph.D.; Department Head, Department of Cellular Biology, Genomics Institute of the Novartis Research Foundation, San Diego, CA' Associate Professor, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA
In this episode, Dr. Elizabeth Winzeler shares her strategy to tackle malaria, a disease that affects 250-500 million people per year.
We talk with Professor Jeffrey Hangst of the ALPHA Collaboration about the successful trapping of anti-hydrogen to hopefully answer some of our most important questions about the universe.
We talk with Professor Jeffrey Hangst of the ALPHA Collaboration about the successful trapping of anti-hydrogen to hopefully answer some of our most important questions about the universe.
We discuss Justin's work on brain machine symbiotic devices, to identifying the key elements in autoimmune disease, to the race between transcription and translation; it's genetics gone wild.
Papers discussed:
1) First cystic fibrosis drug advances towards approval (2011). Nature Biotechnology 29:465-466
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
Abstract
How can species remain unaltered for long periods yet also undergo rapid diversification? By linking genetic variation to phenotypic variation via environmental stress, the Hsp90 protein-folding reservoir might promote both stasis and change. However, the nature and adaptive value of Hsp90-contingent traits remain uncertain. In ecologically and genetically diverse yeasts, we find such traits to be both common and frequently adaptive. Most are based on preexisting variation, with causative polymorphisms occurring in coding and regulatory sequences alike. A common temperature stress alters phenotypes similarly. Both selective inhibition of Hsp90 and temperature stress increase correlations between genotype and phenotype. This system broadly determines the adaptive value of standing genetic variation and, in so doing, has influenced the evolution of current genomes.
Dr. Judith Campisi's scientific investigations are at the nexus between cancer and aging. She seeks to better understand how cellular senescence contributes to the pathophysiology of aging.
Saturday, November 19, 2011 at 07:57PM 