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This netcast explores the rapidly changing world of biotech, with a penchant towards getting a better understanding of who we are and where we are going. The living world will soon be a true substrate for engineering. Our world will change, and so will we. 
We bring a first hand account from the scientists that are moving us into this new technological era: the era of biotech. 

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    FiB Episode 002 - The Genetics of Youth with Dr. Leonard Guarente.

    Dr. Leonard Guarente has identified the genes that could extent the human lifespan...

    Will biotechnology allow us to live healthy and active lives well into our 100s? When the Novartis Professor of Biology at MIT says that it is not only possible, but a pill may be available within 10 years, it seems clear that we have entered new era of modern biotechnology.

    Dr. Guarente started his work by studying aging in brewers yeast. In those experiments he identified a gene, called SIR2, that was responsible for dramatically extending the life span of yeast. It was soon found in other organisms such as round worms, fruit flies, and even mammals including humans for which there are 7 orthologs (or versions). The quest that has gone on since the pharaohs of Egypt, is now over, at least for all the models organisms tested to date! Are we next?

    Would it be possible use this knowledge to delay the onset of age-related diseases such as diabetes and cancer? Dr. Guarente is working on the fundamental processes of aging in his lab, and the company he founded, Elexir Pharmaceuticals, is engineering the pharmacological solutions!

    For more on Dr. Guarente’s work: the Guarente Lab
    Also: Ageless Quest: One Scientists Search for Genes That Prolong Youth


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    • Response
      Response: service essays
      Biotechnology is one of the best technology in this world and it has a great scope in the medical field. I believe that choosing this field is a great decision for someone.There are so many websites on the internet that has great information about Biotechnology and they can help us to ...
    • Response
      Thanks-a-mundo for the weblog. Really cool.

    Reader Comments (8)

    This area of research if very interesting indeed. I have been reading Ray Kurzweil's book "The Singularity is Near - When humans transcend biology" and it is very thought provoking. It seems that alot of people in this area of research seem to think human life expectancy could take a major jump in the next 10-30 yrs.

    July 20, 2006 | Unregistered CommenterSteven

    Another great show guys. Well done!

    I don't wanna sound a bit like a nazi here and I don't believe I am but well here goes.

    I have always wondered how long a human being lived if he/she ate perfectly from birth. Take a human specimen who has a good genetic makeup , for example no genetic markers for disease and stuff like that. From birth feed this human perfectly in a perfect atmosphere. No unhealthy foods all organic. Provide the human subject with every thing healthy and nothing that could effect his inner body adversely.

    Our morals would probably not allow this to happen but I guess what I am saying is how long do you think a human being could live if these things where done.

    July 23, 2006 | Unregistered CommenterSteven

    Great episode. As someone in the pharmaceutical industry with an eye towards biotech, these podcasts are great. I'm sure the first episode was over a lot of people's heads, but with biotech you have to understand the vernacular to really be able to discuss what's going on. Keep up the great interviews!

    July 24, 2006 | Unregistered CommenterChris

    Great podcast. As someone finishing my final year of pharmacy school with an eye toward the biotech industry, these podcasts are great thought provokers. I know the first episode was a little "weighty" for many who are more lovers of tech (i.e. computers) versus biotech, but the price of admission to any new technology is learning the vernacular. Though a physicist, any thoughts on trying to get the great Michio Kaku on in the future? I know he has some fascinating thoughts on where the biotech industry can take the human race.

    July 24, 2006 | Unregistered CommenterChris

    I must say FiB is going to be the number one podcast for Science if you keep this up. Episode two is just amazing. It’s great how you interview the best in the field and touch base on topics that are on the cutting edge of Biotech.

    Now I'm confused about the Caloric Intake discussion. Now when you inhibit the Caloric Intake of a Mammal, they stop reproducing? Which means behavior changes and they are not interested in mating and succeeding? Or no reproductive cells (or few) are produced?

    July 25, 2006 | Unregistered CommenterDustin D

    This was very interesting! The efforts to crack the code and figure out how to keep living systems from failing is fascinating stuff!

    What's next from FiB? I heard some time ago about a new cancer therapy that used some kind of virus that specifically infected cancer cells and caused those cells to produce more of that virus so that other cancer cells could be infected. The result was a therapy that could be injected subcutaneously and completely eradicate the cancer.

    Of course, its targetted to a very specific kind of cancer, but it sounded absolutely fascinating.

    The baby boomers (I'm not one, but my parents are two of them) are definitely driving the biotech industry forward in their attempt to stay young and beautiful!

    Anyways, this is a really neat podcast, and I'm looking forward to more of them!

    July 31, 2006 | Unregistered CommenterScott

    Proabably you guys can check this book :
    it would seem that there are other science of turning back the years around that do not revolve around calorie restricion going on.

    August 7, 2006 | Unregistered Commenterlow

    Maybe you guys would like to check this book out :

    which is science that is going on about turning back the years too but which does not focus on calorie restriction.

    August 7, 2006 | Unregistered Commenterlow

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