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This netcast explores the rapidly changing world of biotech, with a penchant towards getting a better understanding of who we are and where we are going. The living world will soon be a true substrate for engineering. Our world will change, and so will we. 
We bring a first hand account from the scientists that are moving us into this new technological era: the era of biotech. 

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    FiB Episode 005 - On DNA Microarrays with Dr. Andre Nantel

    Dr. Andre Nantel explain how we can capture a picture of the genome in action

    In this episode, we talk about how microarrays are revolutionizing biomedical sciences. Just ten years ago, all genetic and biochemical experiments were performed on a scale of one to a few genes (DNA) or proteins at a time. Now with the advent of microarrays, hundreds of thousands of DNA or protein samples can be analyzed in parallel experiments (side by side on a chip) in a matter of hours. Where once we could only determine whether or not the expression of a single gene was turned on or off using a technique called northern blotting, the dynamic interplay of an entire genome in response to environmental cues or disease states can be monitored in a single experiment. We are slowly transitioning to a new era of individualized medicine, where preventive or therapeutic approaches will be tailored specifically to each individual.

    You'll find André's picture of a DNA microarray being printed here, and an image of a DNA microarray in a scanner. Great shots André! He is an excellent photographer. His photoblog Digital Apoptosis is certainly worth a visit.

    About Dr. Nantel:

    Andre Nantel, M.Sc., Ph.D.
    Research Officer, National Research Council of Canada

    André Nantel is a Research Officer and Project Manager of the Microarray Lab at the NRC Biotechnology Research Institute in Montreal. He is also an Adjunct Professor at the Department of Anatomy and Cell Biology of McGill University. His group runs a facility for the design, production and utilization of DNA microarrays and he is part of an international effort that recently completed the final assembly and annotation of the genome of the fungal pathogen Candida albicans. He is also involved in the interpretation of a large number of transcriptional profiling projects in the fields of cancer research, molecular diagnostics and pathogenesis. Outside of DNA microarrays, his current research interests include the study of signal transduction pathways in cancer, more specifically the roles of adapter proteins in the modulation of kinase cascades. The BRI's Microarray laboratory provides microarrays to academic and research groups worldwide as well as private companies in Canada. The laboratory also assists NRC Genomics research projects and collaborators from academia or the industry.

    http://www.bri.nrc.gc.ca/microarraylab/

    http://www.digitalapoptosis.com/archives/Science.html
    http://www.digitalapoptosis.com/

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    • Response
      When step into professional life, that world is completely different. In order to survive in that you need to be fully prepared because if you are not prepared than it will cost you. For preparation education is the best course of action.

    Reader Comments (2)

    Great show.
    I only knew a little about microarrays. Well only that they existed. Thanks for the podcast Marc!

    Keep them comming. And dont make me wait so long for them. :-)
    Every week or every 2 weeks is fine. But maybe announce it, like is it a bi-weekly podcast or a monthly. Or maybe i missed that and that i am the only asking it.

    But again thanks.

    September 22, 2006 | Unregistered CommenterSeenD

    The interviewing skills are getting much better. Well done Marc!

    October 2, 2006 | Unregistered CommenterCMN

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