Futures in Biotech 77: How the Environment and a Single Protein Influence Evolution
Sunday, March 13, 2011 at 11:04AM Hosts: Marc Pelletier
Drs. Susan Linquist and Daniel Jarosz explain how the environment can drive evolution at the molecular level.
Guests: Susan Lindquist, Ph.D. and Daniel Jarosz, Ph.D.
PAPER PRESENTED:
Science. 2010 Dec 24;330(6012):1820-4.
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
Abstract
How can species remain unaltered for long periods yet also undergo rapid diversification? By linking genetic variation to phenotypic variation via environmental stress, the Hsp90 protein-folding reservoir might promote both stasis and change. However, the nature and adaptive value of Hsp90-contingent traits remain uncertain. In ecologically and genetically diverse yeasts, we find such traits to be both common and frequently adaptive. Most are based on preexisting variation, with causative polymorphisms occurring in coding and regulatory sequences alike. A common temperature stress alters phenotypes similarly. Both selective inhibition of Hsp90 and temperature stress increase correlations between genotype and phenotype. This system broadly determines the adaptive value of standing genetic variation and, in so doing, has influenced the evolution of current genomes.
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